Heavy metals in hair and urine mineral analysis

2010-01-31T10:56:00.001-08:00

Heavy Metal Assessment in Hair Analysis

As long as metals circulate in the blood stream, the hair root is supplied with essential or toxic elements. When metals are tightly bound and fixed to various organs, they no longer circulate in significant concentrations. Blood values will be inconspicuous and go unnoticed. Similarly, the hair is no longer supplied with significant amounts of essential or toxic metals: Hair concentrations will drop over time.

Urinary excretion levels are a direct indication of the chelating substances effectiveness, and a provocation with the appropriate chelating substance (also called urine challenge) can provide surprising results.

The German toxicologist Dr. Daunderer wrote years ago about Hashimoto: „the true cause is amalgam.” DMPS and/or DMSA detoxify the thyroid (among other organs).

Chemical function of chelating agents

2010-01-31T10:53:00.001-08:00

Molecular weight of chelating agents

The question how the molecular weight (MW) of a chelating substance such as EDTA, DMSA or DMPS influences metal binding, has been brought to our attention.

Heinz Scholz, pharmaceutical chemist and journalist explains:
The EDTA-Anion has 2 free nitrogen atoms and 4 carboxyl groups i.e. it can bind 6 kations. Its MG = 292,2
DMSA: MG = 188,2; it has 2 SH-Groups
DMPS: MG = 188,3; it has 2 SH-Groups

It would be a fallacy to assume that EDTA, due to the higher MW, is a more effective chelating agent.

What we need to know

a) In Toxicology, we do not have a chelating substance or Antidote that treats all. There is no such miracle agent.

b) The EDTAs like the DTPAs are oxygen-affine chelating substances; DMSA und DMPS are sulfuraffine. It is this affinity which determines the specificity of the various chelating agents, what metal is best bound and which one not. The molecular weight is secondary. This affinity explains why mercury is strongly bound by the sulphur-affine chelating substances DMSA and DMPS and not by the EDTA or DTPAs.

c) How much of a chelating substance we administer plays a crucial role. For example, the infusion of 2gr EDTA over 2hrs will result in less metal binding then the administration of 3gr EDTA in 3hrs, which is also 1gr/hr. Similarly, 100mg of oral DMSA will bind, mathematically spoken, 10x less than 1000mg or orally administered DMSA. An ampule containing 250mg DMPS will have a greater metal-binding effect than a 100mg capsule of DMPS.

d) The method of administration influences metal binding and metal excretion. An infusion or injectable quickly reaches the blood stream and becomes active; the renal canal is more easily affected and detoxified. The content of a capsule is first active in the digestive tract where it quickly and easily binds available metals. The digestive tract is first detoxified before the oral chelator reaches the blood stream. The more metals are found in the digestive tract, the less of the chelators ‘claws’ are free for additional binding elsewhere. It is thus logical to detoxify the digestive tract before chelation is started, or acknowledge that fecal matters carry a heavy metal load.
These are some of the topics of our workshops. We particularly discuss the necessity of following protocols and why certain procedures are necessary to achieve results. More under www.microtrace.de

Environmental Toxicology - Team Knowledge

2010-01-27T03:49:00.000-08:00